As determined via SCIENCE. Note that a few of these were released in late 2015 but spent a majority of their time on playlist in 2016, and thus qualified for inclusion.
| rank | artist | title | label |
| 1 | Daniel Bachman | Daniel Bachman | Three Lobed |
| 2 | See Gulls | Curtain Call | Potluck |
| 3 | Dex Romweber | Carrboro | Bloodshot |
| 4 | Hiss Golden Messenger | Heart Like a Levee | Merge |
| 5 | Mount Moriah | How to Dance | Merge |
| 6 | Various Artists | Save the Pinhook! | self-released |
| 7 | Le Weekend | It Can't Be Youth | Potluck |
| 8 | Angel Olsen | My Woman | JagJaguwar |
| 9 | Boulevards | Groove! | Captured Tracks |
| 10 | Flock of Dimes | If You See Me, Say Yes | Partisan |
| 11 | Nathan Bowles | Whole & Cloven | Paradise of Bachelors |
| 12 | Loamlands | Sweet High Rise | Middle West |
| 13 | Paint Fumes | If It Ain't | Get Hip |
| 14 | Tashi Dorji & Shane Parish | Expecting | MIE Music |
| 15 | Phatlynx | Loosen Yer Belt! | NDM Ltd |
| 16 | Southern Culture on the Skids | The Electric Pinecones | Kudzu |
| 17 | Davidians | City Trends | Sorry State |
| 18 | al Riggs | Night Freedom | self-released |
| 19 | Horseback | Dead Ringers | Relapse |
| 20 | Sarah Louise | Solo Acoustic Vol. 12 | VDSQ |
| 21 | Moon Racer | 2 Songs | self-released |
| 22 | Some Army | One Stone and Too Many Birds | Potluck |
| 23 | Body Games | Damager | self-released |
| 24 | 9th Wonder | Zion | Jamla |
| 25 | Jenks Miller and Rose Cross NC | Blues from WHAT | Three Lobed |
| 26 | Whatever Brains | Whatever Brains (2015) | Sorry State |
| 27 | The Bronzed Chorus | Summering | Double+Good |
| 28 | Humanize | Sadlands | Winsome |
| 29 | Chatham County Line | Autumn | Yep Roc |
| 30 | Beauty World | Joypop Turbo | Potluck |
| 31 | Naked Naps | The Middle | self-released |
| 32 | AL Riggs and the Inconveniences | Husbands | self-released |
| 33 | Liquid Asset | Colony Denied | Primitive Languages |
| 34 | Museum Mouth | Popcorn Fish Guinea Pig | Equal Vision |
| 35 | Kleptonaut | On the Up and Up | self-released |
| 36 | Magpie Feast | To Keep It All Spinning | self-released |
| 37 | Skylar Gudasz | Oleander | Daniel 13 |
| 38 | Wild Fur | Feel Free | Potluck |
| 39 | MAKE | Pilgrimage of Loathing | Accident Prone |
| 40 | al Riggs | Blue Mornings | self-released |
| 41 | Secret Boyfriend | Haunt Stress/Burned Version/Forget to Breathe | self-released |
| 42 | Vaxxers | The Cold Steam Engine | self-released |
| 43 | al riggs | Breakdowner and the Hungry Months | self-released |
| 44 | Nancy Middleton | Loaded | self-released |
| 45 | Malcolm Holcombe | Another Black Hole | Proper |
| 46 | Blursome | Age | self-released |
| 47 | Brice Randall Bickford | PARO | self-released |
| 48 | Etta Baker | Railroad Bill | Music Maker Relief Foundation |
| 49 | Rebar | Rebar | self-released |
| 50 | Arrogance | Knights of Dreams | Numero Group |
| 51 | Cyanotype | Two Silent Schnauzers | Out & Gone Music |
| 52 | CALAPSE | Welcome to Planet Goo | self-released |
| 53 | Knives of Spain | Telluric | Hairy Spider Legs |
| 54 | shirlette ammons | Language Barrier | Churchkey/SugarQube |
| 55 | Rapper Big Pooh & Nottz | Home Sweet Home | Mello Music Group |
| 56 | The Dead Tongues | Montana | self-released |
| 57 | Dan Melchior and Russell Walker | In Durham | Kill Shaman |
| 58 | Hiss Golden Messenger | Vestapol | Merge |
| 59 | Kooley High | Heights EP | M.E.C.C.A. |
| 60 | Maple Stave | V | Phratry |
| 61 | Totally Slow | Bleed Out | Negative Fun/Self Aware |
| 62 | No One Mind | No One Mind | Third Uncle |
| 63 | Caleb Caudle | Carolina Ghost | This is American Music |
| 64 | Tuskha | Tuskha | Middle West |
| 65 | Mandolin Orange | Blindfaller | Yep Roc |
| 66 | Dogs Eyes | Measure the Earth | self-released |
| 67 | Konvoi | Konvoi | Snot Releases |
| 68 | Goodbye, Titan | Daedalus | self-released |
| 69 | Patrick Gallagher | Turrem | Refulgent Sepulchre |
| 70 | Body Kit | Demo | self-released |
| 71 | Alpha Cop | Zakouma | self-released |
| 72 | Holder's Scar | Public Acid | self-released |
| 73 | Deltoid | Deltoid | self-released |
| 74 | Beloved Binge | Never, the end | self-released |
| 75 | Jon Shain & Joe Newberry | Crow the Dawn | Flyin' |
| 76 | Tonk | Second Chance | Future Standards |
| 77 | Secret Boyfriend | Memory Care Unit | Blackest Ever Black |
| 78 | Lack | Perhorrences | Hot Releases |
| 79 | Bandages | All Extreme Measures b/w Tokyo Carwash | Sorry State |
| 80 | Human Pippi Armstrong | Everything is Flexible | Djangokill |
| 81 | Sponge Bath | Golden Light | Tone Log Jr. |
| 82 | Todd W. Emmert | Devil's Return | Therapy Tapes |
| 83 | Shallows | The Moon Rises | self-released |
| 84 | Chateau | Moons over Slaughter | self-released |
| 85 | Tegucigalpan | The Fifth of She | self-released |
| 86 | City of Medicine | Bone Coal | self-released |
| 87 | Bad Friends | DEMOLISH | self-released |
| 88 | Laurelyn Dossett | Lullabies and Leave-Takings | self-released |
| 89 | Bloodwritten | We Live in Darkness | self-released |
| 90 | The Honeycutters | On the Ropes | Organic |
| 91 | Housefire | burnthemasters | Hot Releases |
| 92 | Sourvein | Aquatic Cult | Metal Blade |
| 93 | Chateau | Amissus | self-released |
| 94 | Blackball | Blackball | Sorry State |
| 95 | Uninhabitable | Uninhabitable | All We Know/ Dead Tank |
| 96 | Knurr and Spell | Ought | Potluck |
| 97 | Suppressive Fire | Bedlam | self-released |
| 98 | Don Howland | Life is a Nightmare | 12XU Records |
| 99 | Regraped | Play Extremely Loud | Fort Hazel Magic |
| 100 | Heron | DYZU | self-released |
| 101 | Widow | Carved in Stone | Pure Steel |